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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

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Articles 12 Documents

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Search results for , issue "Vol 3, No 1 (2011): Januari-Juni 2011" : 12 Documents clear

The Effect of Tempeh on the Ability of Macrophage Phagocytosis An experimental study in male Balb/c mice Afiyata, Noven; Sarosa, Hadi; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Consuming tempeh regularly increases the levels of isoflavones in the our body influencing the IFNÃ£ and macrophage activating factor (MAF) that lead to the in increase in the ability of macrophage phagocytosis. Macrophage phagocytosis gives an illustration of the macrophages ability as the first line of phagocytic cells to digest foreign particles. This study aims at finding out the influence of tempeh on the ability of macrophage phagocytosis.Design and Methods: In an experimental study using post test only control group design, 15 mice Balb/c were divided into 3 groups of 5 mice each. Gp1: 0.5 gr of tempeh juice, Gp2: 1 mg tablet imboost in 1 cc of water (positive control), Gp3: 1 cc of 1 times (negative control). Treatment was given daily for 12 days. On day 13, Phagocytic ability of macrophages were examined using latex beads method. Data were analyzed using one Kruskal Wallis test followed by Independent T-Test.Results: The phagocytic ability for the three groups were 760,6 -----Â± 109,898 ; 244.2 Â± 70.159; 9.6 Â± 2.839 respectively. Independent t- test resulted in the significance difference (p = 0.008) between treated groups and control groups, both positive and negative ones (p<0,05).Conclusion: There is a difference in phagocytic ability between treatment and control groups (Sains Medika, 3(1):54-62).

The Correlation between the Dimention of Trust among the Member of the Group and the Effectiveness of PBL Tutorial Group Istadi, Yani
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: The tutorial plays a central role in problem-based learning (PBL). The effective implementation of small group tutorials is one of the key contributors to the students success in examinations. This study aimed to identify factors perceived as the predictors for effectiveness of PBL group tutorial.Design and method: The subjects of the study were all of the students (year of 2008) of the Medical College of Sultan Agung Islamic University taking the Tropical Disease Module. The adapted version of the scales adopted in this study included the scale developed by Van den Bossche et al for assessing team (group) effectiveness, trust dimension and learning behavior, a scale developed by Dolmans & Ginns (2005) for assessing tutorâ€™s performance, a 5 points likert scale was used to asses the student opinions. Quantitative approach with correlation and multiple regression analysis was applied.Result: Of 238 students included in the study 84 (37.3%) were male and 139 (62.3%) were female. There was a significantly positive correlation between the trust dimension related to the interpersonal relationship among the members of tutorial group with the effectiveness of tutorial group ( r = 0.631, p< 0.01). There was a medium correlation among cohesion, group potency and psychological (r= 0,700, p < 0.05 there was correlation among the variables of (r = 0,557, p < 0,001), group potency (r = 0,517, p < 0,001), and psychological assurance (r = 0,437, p < 0.001). These three variables contributed to the group effectiveness as much as 48.4% with a F value of 87.857. The component of independence was not found to be the predictive factors for group effectiveness. The correlations among the variables of cohesion, group potency and psychological assurance resulted in contingency coeficien of 0.700 with p<0.05.Conclusion: The higher trust related to the interpersonal relationship among the member of groups, the more effective the group will be. Cohesion, group potency and psychological assurance were found to be the predictive factors for group effectiveness (Sains Medika, 3(1):16-23).

The Difference in Effectiveness of 70% and 0.5% Chlorine to ReduceThe Germ Number on Stethoscopeâ€™s Membrane Experimental research at stethoscope in Baitul Izah Ward of Sultan Agung Islamic Hospital Semarang Pramita, Heny; Saugi Abduh, Saugi Abduh; Chodidjah, Chodidjah
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Recently, nosocomial infection (hospital- acquired infections) is estimated to affects more than 1.4 million of in patients in all over the world. Stethoscope is one source of nosocomial infection caused by the continuous contact from one patient to another. 70% alcohol and 0.5% chlorine can be used for disinfection. The purpose of the research is to find out the difference in the effectiveness of 70% alcohol and 0.5% chlorine to reduce the amount of germ on the stethoscopeâ€™s membrane.Design and Methods: This was an experimental research with the Post Test Only Control Group Design using 18 stethoscopes divided into 3 groups randomly. Group A was the control group (aquabidest), group B were treated with 70% alcohol treatment, and group C was treated with 0.5% chlorine. The research samples were the stethoscopes used to treat patient in Baitul Izah ward of Islamic Hospital of Sultan Agung Semarang. The data on the germ amount was analyzed using Kruskal-Wallis test. Results: There was a significant difference between aquabidest group and 70% alcohol group (p<0.05) and between aquabidest control group and chlorine group(p>0.05), nevertheless, there was no significant difference between the 70% alcohol group and 0.5% chlorine group ( 0.652). Conclusion: There was no difference in the effectiveness between 70% alcohol and 0.5% chlorine to reduce the number of germ on the stethoscopeâ€™s membrane (Sains Medika, 3(1):63-68).

The Correlation between Individual and Environmental Hygiene and Pioderma Incidence An Analytical Observational Study in Pyoderma Patient in Islamic Sultan Agung Hospital during the Period August to December 2010 Sutisna, Iis Aisyah; Harlisa, Pasid; Zulaikhah, Siti Thomas
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Bacterial skin infection is the third most common health problem in Indonesia resulting from poor personal and environmental hygiene. The most common bacterial skin infection is the pyoderma. This study aims to find out relation between personal hygiene and environmental with the incidence of pyoderma in RSI Sultan Agung Semarang.Design and Methods: The study type was analytic observational with case control design. The sample consisted of 30 respondents RSI patients Sultan Agung for case group and 30 persons as control group is the neighbors of patients who have similar characteristics and are not suffering pyoderma. The data used are secondary data from medical records and primary data from questionnaires filled out by respondents, then the data were analyzed with chi-square and to determine the correlation power there was used a contingency coefficient test.Results: It was found that the good and the bad individual hygene for the case group were 3.3% and 66.7% respectively, while for the control group the good and bad individual hygene were 80.0% and 20.0% respectively. Chi-square test resulted in p=0,000 with contingency coefisien of 0.426. It was found that the good and the bad environmental hygene for the case group were 56.7% and 43.3% respectively, while for the control group the good and bad environmental hygene were 83.3% and 16.3% respectively. Chi-square test resulted in p=0,024 with contingency coefisien of 0.27.Conclusion: There was a significant correlation between the personal and environmental hygiene and poderma insicence at the RSI Sultan Agung with a moderate relationship between individual hygiene and weak relationship between environmental hygene (Sains Medika, 3(1):24-30).

The Level of SGOT and SGPT after The Administration of Powdered Colorant Pigment Isolated from Kesumba Kelingâ€™s (Bixa Orellana) Seed Coats An experimental study in Balb/C Mice Suparmi, Suparmi; Isradji, Israhnanto; Fatmawati, Dina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: There has been an effort to explore pigment from kesumba kelingâ€™s (Bixa orellana) seed coats for a source of natural food colorant. Consumption of pigment from kesumba keling (Bixa orellana) was assumed to cause adverse effects on heart as an important organ in detoxification or inactivation of drugs or other toxic compounds. This study conducted to determine the levels of SGOT and SGPT blood serum of mice (Mus musculus) Balb/C after administration of colorant powder pigment of B. orellana seed coatâ€™s at various concentrations.Design and Methods: The research is an experimental research with Factorial Design with 2 factors. Food Colorant Powder was made from bixin, norbixin, and crude extract pigment isolated from B. orellana seed coatâ€™s. A total of 60 male mice were divided into 10 treatment groups. Powdered colorant solution at the concentration of 0% (control), 1%, 5%, and 10% were orally administered using gavage as much as 1 ml a day for 30 days.Results: Kruskal Wallis test results shows a not significant difference SGOT and SGPT level among the groups (p > 0.05), thus consumption of colorant powder of bixin, norbixin, and the crude extract with various concentrations did not affect the SGOT and SGPT.Conclusion: Colorant powder isolated from B. orellana seed coatâ€™s has been shown to have no effect on the liver function, so it is safe as food colorant (Sains Medika, 3(1):69-77).

Hyperexpression of TNF-Stimulated 6 (TSG-6) of HumanTracheal Aspirate and Bronchial Alveolar Lavage from Heavy-Smoker and Lung TB Trihadi, Djoko
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: TSG-6, an inflamation-associated protein, forms covalent complexes with heavy-chains from TNF. These protein potentiating the antiplasmin activity of this serine protease inhibitor. The aim of study was to determine and show that TSG-6 are present in Bronchoalveolar Lavage (BAL) from patients with lung TB and heavy smoker.Design and Methods: Experiments conducted in vitro with purified components revealed that TSG-6 had immunodetection in the Human Tracheal Aspirates (HTA) and BAL of heavy smoker and Lung Tuberculosis.Results: Immunoprecipitation revealed that TSG-6 accounts in airways hyperresponsiveness for significant proportion of BAL and HTA, but not in control (p < 0,01). TSG-6 relevant protease inhibitor in airway secretion. In primary cultures of differentiated human airway epithelial, which suggest that TSG-6 may be induced by TNF. Our results suggest that TSG-6 may play an important protective role in bronchial epithellium buy increasing the antiprotese screen on the airway lumen. The present study identifies a novel function of TSG-6 by a distinct mechanism system regulated, enhancement of anti TK activity, and provides a rational for this activity within the context of inflamed airways. These findings correlate with the observed increases in protein expressions in human HTA and BAL.Conclusions: TSG-6 are hyper-expressed in airway epithelial cells in cultures of smoker and lung TB. The interactions of TSG-6 with other molecules are also potentially important to the pathophysiologic aspects of inflammatory airways diseases that remain to be elucidated (Sains Medika, 3(1):31-40).

The Length of Stay Difference between Under 5 Years Patient with Acute Diarrhoea Treated With and Without Probiotic An Analytical Study in RSUD Kota Semarang during the Period January to December 2007 F. Riandari, F. Riandari; Priyantini M., Sri
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Diarrhoea is still public health problem and often cause outbreak with various morbidity and mortality. The long onset of acute diarrhoea causes the length of stay that affect the cost. So proper management is needed to shorten inpatient length of stay. Probiotic can make the convalescence of children with acute diarrhoea faster. The aim of the study is to know the lenght of stay difference between underfive year old children with acute diarrhoea treated with and without probiotic.Design and Methods: The study was an analitical study with case control design. Study Sample were all inpatient 6-24 month old children with acute diarrhoea in Kota semarang Hospital since January â€“ December 2007. Data were obtained from medical record in pediatric unit. Data analysis with stastitical test of Mann Whitney.Results: Of 130 samples, the lenght of stay average of < 5 years old children with acute diarrhoea with probiotik was 3,42 days compare 4,03 days children acute diarrhoea without probiotik. It is concluded that there was a significantly difference between two groups acute diarrhoea with probiotik and without probiotik.Conclusion: There was a significant difference between the length of stay for the patients with acute diarrhea with and without probiotic treatment. Mean of the length of stay for under 5 years old baby with and without probiotic were 3.42 days and 4.03 days respectively (Sains Medika, 3(1):78-83).

The Effect of Honey Administration on Gastrohistopathological Image Study In Male White Wistar Rat Induced With Indomethacin Suprijono, Agus; Trisnadi, Setyo; Negara, Henri Perwira
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Gastric disorder often generates clinical symptoms such as gastritis or peptic ulcer. Bee honey has high nutrient has been shown to have a protective effect against drugs destroying stomach. The purpose of this study was the difference effect of honey in various concentrations on the gastrohistopathological image in male white Wistar rat induced with indomethacin. Design and Methods: This was an experimental research using control group post test design. 24 male white rats Wistar were randomly divided into 6 groups of 4 mice each. Group I served as the control group (standar and aquades), group II: 3.78 mg of indometachin, group III: 3.78 indomethacin and 3.6 ml honey (25%,) group IV: 3.78 indomethacin 3.6 ml honey (50%,) group V: 3.78 mg indomethacin 3.78 mg and 3.6 ml (75%(), group VI: 3.78 indomethacin 3,78 mg and honey 3.6 ml 100%. Treatment given by sonde once a day for 15 days. the gastrohistopathological image was evaluated for degree of gastritis and degree of peptic ulcer. The data were tested with test Kruskal-Wallis followed by Mann-Whitney test. Results: Kruskal-Wallis test showed at least significant differences in the degree of gastritis and peptic ulcer between between the two groups (p <0.05). Mann-Whitney test howed that not all groups compared to control showed a significant different in the degrees of gastritis and peptic ulcer. Conclusion: The study suggested that honey have effect on the gastrohistopathological image of indomethacin-induced stomach (Sains Medika, 3(1):41-47).

Cytomegalovirus Congenital Cataract Wahyutomo, Ridha
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Cytomegalovirus congenital infection is an infection caused by the the subfamily Ã¢ Herpesviridae, during pregnancy. The incidence of infections among newborn infants is 1 %. One of the effects of congenitally acquired infection is the congenital cataract. A 6-year-old child complained to have a blurred vision diagnosed with cytomegalovirus congenital cataract. The diagnosis was confirmed by a positive serology testing for Ig M and Ig G CMV. The laboratory test using Giemsa staining to find inclusion bodies and a faster PCR could not be carried out (Sains Medika, 3(1):84-88).

The Trial on the Effectiveness of Honey on White Rats Using Geliate Acetate Method An Experimental Study in Male Wistar Rat Goenarwo, Edijanti; Chodidjah, Chodidjah; Susanto, Heri
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Pain is the most common complaint of a disease that can be reduced using the analgesic drugs. Besides the pharmacological medication, the traditional medications are available including honey containing flavanoid. The compound can protect the lipid membrane from the damage and inhibit cyclooxygenase, the main path of the synthesis mediator for pain like prostaglandin. This study aims at finding out the efficacy of analgesic of honey using geliate asetate method.Design and methods: In an experimental study using post test only control group design, 25 Wistar rat (80-90 days, BW 180-220 gr) were randomly divided into 3 groups of 5 mice each. Gp1: =aquadest (negative control), Gp2: 0.675 g/BW honey, Gp3: 1.35g honey Gr 4: 2.7 g/kgBW honey and Gr 5 (possitive control): 4.5 mg/ BW of paracetamol. 5 minutes after the treatment, an intraperitoneal injection of acetic acid was given for all groups. Anova followed by post Hoc test was used for data analysis.Result: The honey concentration of 50% (1.35) g was found to have increasing effect of analgesic while the concentration of 25% and 100 % showed a reducing analgesic effect.Conclusion: Honey has been shown to have an analgesic effect in mice with the effective concentration of 50% (1.35 g/kgBW) (Sains Medika, 3(1):48-53).

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